Thematic is an open-source theme framework designed as a starting point for simple customisation, which also happens to look pretty darn good out of the box.
It features classy search engine optimisation, multiple widget-ready areas (not just in sidebars and footer but between posts, above posts etc.), and a grid-based design.
The included stylesheets are aligned to a strict 18px vertical grid featuring refreshing and sophisticated typography.
Demo and download:
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